A key role for redox signaling in rapid P2X receptor-induced IL-1β processing in human monocytes
Journal of Immunology, ISSN: 1550-6606, Vol: 180, Issue: 12, Page: 8410-8420
2008
- 101Citations
- 76Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations101
- Citation Indexes101
- 101
- CrossRef97
- Captures76
- Readers76
- 76
Article Description
P2X receptors (P2XRs) are ATP-gated ion channels that trigger caspase-1 activation in the presence of TLR ligands. Inflammatory caspase-1 is responsible for the proteolytic activation of IL-1β. However, the signaling events that couple P2XRs to caspase-1 activation remain undefined. In this study we demonstrate that ATP-induced cellular oxidation is critical for caspase-1 activation and subsequent IL-1β processing. Purinergic receptor stimulation, including P2XRs, of endotoxin-primed human monocytes augments NADPH oxidase activity whereas concurrent purinergic receptor stimulation triggers protein denitroyslation, leading to the formation of peroxynitrite. IL-1β cleavage is blocked under conditions where superoxide anion formation is blocked or monocytes are treated with antioxidants or a peroxynitrite scavenger. Nigericin, a K /H antiporter, also increases NADPH oxidase activity, leading to IL-1β and caspase-1 processing that is blocked by a peroxynitrite scavenger or inhibition of NADPH oxidase. These data demonstrate that signaling via NADPH oxidase activity is fundamental for the processing of mature IL-1β induced by P2XR stimulation. Copyright © 2008 by The American Association of Immunologists, Inc.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=50249090764&origin=inward; http://dx.doi.org/10.4049/jimmunol.180.12.8410; http://www.ncbi.nlm.nih.gov/pubmed/18523309; https://journals.aai.org/jimmunol/article/180/12/8410/43964/A-Key-Role-for-Redox-Signaling-in-Rapid-P2X7; https://dx.doi.org/10.4049/jimmunol.180.12.8410
Oxford University Press (OUP)
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