A critical analysis of ejection fraction
Revista Medica de Chile, ISSN: 0717-6163, Vol: 150, Issue: 2, Page: 232-240
2022
- 6Citations
- 5Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations6
- Citation Indexes6
- Captures5
- Readers5
Article Description
Ejection fraction (EF) is defined by the ratio of end-systolic volume (ESV) and end-diastolic volume (EDV). The resulting fraction is a dimensionless number whose interpretation is ambiguous and most likely misleading. Despite this limitation, EF is widely accepted as a clinical marker of cardiac function. In this article we analyze the role of ESV, a fundamental variable of ventricular mechanics, compared with the popular EF. Common physiology-based mathematics can explain a simple association between EF and ESV. This concept is illustrated by a detailed analysis of the information obtained from angiocardiography, echocardiography and cardiac magnetic resonance studies. EF versus ESV produces a non-linear curve. For a small ESV, the EF approaches 100%, while for a large ESV, the EF gradually decreases toward zero. This elemental relationship is commonly observed in innervated natural hearts. Thus, the popularity of EF mostly derives from a fortuitous connection with the pivotal variable ESV. Alongside this finding, we unfold historical events that facilitated the emergence of EF as a result of serendipity. Our physiology-based approach denounces the circumstantial theories invoked to justify the importance of EF as an index of cardiac function, which are critically discussed. EF appears to be nothing more than a blessing in disguise. For this reason, we propose the ESV as a more logical metric for the analysis of ventricular function.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85135587261&origin=inward; http://dx.doi.org/10.4067/s0034-98872022000200232; http://www.ncbi.nlm.nih.gov/pubmed/36156650; http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872022000200232&lng=en&nrm=iso&tlng=en; https://dx.doi.org/10.4067/s0034-98872022000200232; https://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872022000200232&lng=en&nrm=iso&tlng=en
SciELO Agencia Nacional de Investigacion y Desarrollo (ANID)
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