How general anesthetics work: from the perspective of reorganized connections within the brain
Korean Journal of Anesthesiology, ISSN: 2005-7563, Vol: 75, Issue: 2, Page: 124-138
2022
- 6Citations
- 51Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations6
- Citation Indexes5
- Policy Citations1
- Policy Citation1
- Captures51
- Readers51
- 51
Review Description
General anesthesia is critical for various procedures and surgeries. Despite the widespread use of anesthetics, their precise mechanisms remain poorly understood. Anesthetics inevi-tably act on the brain, primarily through the modulation of target receptors. Even if the action is specific to an individual neuron, however, long-range effects can occur due to the tremendous interconnectedness of neuronal activity. The strength of this connectivity can be understood using mathematical models that allow for the study of neuronal connectivity dynamics. These models also allow researchers to develop hypotheses on the candidate mechanisms of action of different types of anesthesia. This review highlights the theoreti-cal background associated with the study of the mechanisms of action of anesthetics. We propose a candidate framework that describes how anesthetics act on the brain and consciousness in general.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85128244902&origin=inward; http://dx.doi.org/10.4097/kja.22078; http://www.ncbi.nlm.nih.gov/pubmed/35130674; http://ekja.org/journal/view.php?doi=10.4097/kja.22078; https://dx.doi.org/10.4097/kja.22078; https://ekja.org/journal/view.php?doi=10.4097/kja.22078
The Korean Society of Anesthesiologists
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