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Prolonged remission in a child with chronic myeloid leukemia following Parvo virus B19 (B19V) infection

Indian Journal of Medical Microbiology, ISSN: 0255-0857, Vol: 33, Issue: 3, Page: 432-434
2015
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Metric Options:   Counts1 Year3 Year

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Case Description

Parvovirus B19 (B19V) has been associated with a wide spectrum of clinico-pathological disorders in human beings depending upon the host immunity. The present report describes a child with chronic myeloid leukemia ( CML) on hydroxyurea in haematological remission, who developed profound erythroid suppression following B19V infection requiring multiple transfusions and withdrawal of hydroxyurea. Despite being off-therapy the child remained in complete clinical and haematological remission till anti B19V antibodies appeared. This case illustrates the ability of B19V infection in suppressing neoplastic myeloid clone, a phenomenon not described earlier.

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