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Apolipoprotein B gene mutation related to familial hypercholesterolemia in an Iranian population: With or without hypothyroidism.

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, ISSN: 1735-1995, Vol: 26, Issue: 1, Page: 94
2021
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Article Description

Familial hypercholesterolemia (FH) leads to elevated low-density lipoprotein cholesterol (LDL-C) levels in plasma. Mutations of its related gene; apolipoprotein B (APOB) is seen in about two percent of the patient with FH. Thyroid disease is usually part of the exclusion criteria for the detection of FH which alters the lipid profile. We evaluated mutations in the gene in patients with high LDL-C levels.

Bibliographic Details

Vaseghi, Golnaz; Malakoutikhah, Zahra; Shafiee, Zahra; Gharipour, Mojgan; Shariati, Laleh; Sadeghian, Ladan; Khosravi, Elham; Javanmard, Shaghayegh Haghjooy; Pourmoghaddas, Ali; Laher, Ismail; Zarfeshani, Sonia; Sarrafzadegan, Nizal

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