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Challenges in antimalarial drug discovery

Future Medicinal Chemistry, ISSN: 1756-8919, Vol: 3, Issue: 11, Page: 1401-1412
2011
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Review Description

Malaria is one of the most devastating diseases in the world, affecting almost 225 million people a year, and causing over 780,000 deaths, most of which are children under the age of 5 years. Following the recent call for the eradication of the disease, supported by the WHO, there has been increasing investment into antimalarial drug-discovery projects. These activities are aimed at generating the next generation of molecules focused on the treatment and transmission-blocking of Plasmodium falciparum and Plasmodium vivax endo- and exo-erythrocytic stages of the parasite. This article summarizes the current top-level thinking regarding the prosecution of such endeavors and the disease-specific considerations in project planning. © 2011 Future Science Ltd.

Bibliographic Details

Burrows, Jeremy N; Leroy, Didier; Lotharius, Julie; Waterson, David

Informa UK Limited

Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics

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