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Post-Gastric-Bypass Hypoglycemia Successfully Treated With Alpha-Glucosidase Inhibitor Therapy

Endocrine Practice, ISSN: 1530-891X, Vol: 19, Issue: 3, Page: 511-514
2013
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Metric Options:   Counts1 Year3 Year

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Review Description

To review the effectiveness of alpha-gluco- sidase inhibitor (AGI) therapy in the treatment of hypoglycemia after Roux-en-y gastric surgery. Retrospective case review. Four patients who previously underwent Roux-en-y gastric bypass were evaluated because of severe symptomatic postprandial hypoglycemia that was unresponsive to a low-carbohydrate diet. Mixed-meal testing confirmed hyperinsulinemia. Other causes of hypoglycemia were ruled out by a combination of clinical examination, endocrine testing, and computed tomography imaging. Symptomatic hypoglycemia resolved in all 4 patients after AGI therapy was started. One patient could not tolerate long-term therapy because of a rash. The other 3 patients were followed for between 5 and 48 months and remained free of symptomatic postprandial hypoglycemia. AGI therapy is effective in the long-term treatment of post-Roux-en-y hypoglycemia in patients unresponsive to a low-carbohydrate diet. To our knowledge, this is the first report documenting the long-term usefulness of this therapy in a series of patients. (Endocr Pract. 2013;19:511-514)

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