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Controlling Characteristics of Glycine Crystals by Reactalyzer

Journal of the Society of Powder Technology, Japan, ISSN: 1883-7239, Vol: 59, Issue: 9, Page: 459-463
2022
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Article Description

Continuous crystallization is the next step of manufacturing especially at the production of pharmaceutical ingredients. We have developed small-scale continuous taylor-vortex crystallizer that is suitable for research in laboratory. But there was a problem that rotating inner cylinder at high-speed range causes much frictional heat and it raises the temperature of the solution, that may spoil the effort of controlling characteristics of crystals. So, we have developed new taylor-vortex crystallizer that has inner cooling system. We conducted several examinations of antisolvent crystallization of glycine, which aims to obtain unstable crystal polymorph of glycine continuously. The new crystallizer showed the advantage of crystallizing unstable crystal polymorph.

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