Organozinc reagents in a flow-microreactor -from methylenation to asymmetric autocatalysis

A flow-micro reactor can integrate the simple reactions to complete the molecular transformation consisting from many steps. Especially, it can set the most preferable reaction conditions including the temperature and the period to each reaction; the sequence of steps is also able to be planned precisely either in linear or parallel configuration. The method had already shown the great success in the flash chemistry, which uses reactive, unstable, and short-lived intermediates to perform the multi-step organic synthesis efficiently in the flow. On the other hand, a flow-micro reactor shows the efficiency in the classical one-pot reaction, as it can exclude the sensitive product from the starting substrate and the reagent by a flow. We introduced our recent results of the selective methylenation of telephthaldehyde and [6+1] type cycloheptane-ring synthesis using a micro-flow reactor. In addition, we show the Soai asymmetric autocatalysis and amplification reaction by a micro-flow system. The system show the high performance of the Soai reaction clearly and efficiently; the amplification of enantiomeric excess was observed clearly.