Spectrophotometry Method for Determination of Mannitol in Injectable Formulation
Research Journal of Pharmacy and Technology, ISSN: 0974-360X, Vol: 17, Issue: 7, Page: 3177-3180
2024
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Amity University Researcher Publishes New Studies and Findings in the Area of Pharmacy and Technology (Spectrophotometry Method for Determination of Mannitol in Injectable Formulation)
2024 SEP 13 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Drug Daily -- Current study results on pharmacy and technology have been
Article Description
Mannitol, an osmotic diuretic derived from naturally occurring alcohols in plants and fruits, is one such substance. Mannitol was discovered in 1806 by Joseph Louis Proust. Because of its ability to promote dehydration, mannitol is also used in neurosurgery and neurology. Ocular pressure should be reduced by using Mannitol. Because it is eliminated unaltered via the kidneys, impaired renal function results in cellular dehydration. Mannitol is well known excipient used in preparation of solid dosage forms. The development of suitable analytical method is essential part of drug development. Various methods for the determination of Mannitol in different matrices are available in literature. Most of them particularly chromatography methods are tedious and expensive. Because of the linear structure of structure of molecule and absence of suitable chromophore, it is difficult to develop any direct spectrophotometry method. Thus, the aim of presented study is to develop simple, economical, sensitive, and accurate method for determination of Mannitol in injectable formulations. The developed method after validation as per ICH guidelines, successfully utilized for analysis of marketed formulation.
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