A combination of ursodeoxycholic acid and Allium sativum prevents liver cirrhosis in cholestatic rats
Journal of Advanced Biotechnology and Experimental Therapeutics, ISSN: 2616-4760, Vol: 8, Issue: 1, Page: 192-199
2025
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Cholestasis causes liver cirrhosis due to chronic total obstruction, in which accumulated bile acids induce liver inflammation and fibrosis. Inflammatory conditions are associated with hypoalbuminemia, and changes in albumin levels indicate the patient's clinical condition. Allium sativum has anti-inflammatory, antioxidant, and antifibrotic effects against various diseases. Further, ursodeoxycholic acid (UDCA) is one of the few available therapies for cirrhosis. Thus, this study aimed to assess the combination of A. sativum and UDCA as standard therapy in preventing liver cirrhosis and cholestasis. The current study was carried out with 35 male Sprague Dawley rats, which were randomly assigned into healthy, negative, and positive control groups, and three treatments of UDCA and graded doses of A. sativum extract. Biliary duct ligation was used for inducing cholestasis, and the treatment was given for 21 days. Liver cirrhosis was assessed based on Laennec grade by histopathological examination. Albumin levels are measured by examining blood serum. The combination of UDCA and A. sativum extract significantly reduced the degree of liver fibrosis and increased albumin levels in mice with cholestasis (p<0.05). There was no difference in the degree of liver fibrosis between the graded doses of A. sativum. Albumin levels were significantly correlated with the degree of liver fibrosis (p<0.05). In conclusion, the data suggest that A. sativum administration can be combined with UDCA to increase the hepatoprotective effect against cholestasis in rats.
Bibliographic Details
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know