Physical and functional interaction between 5-HT receptor and nova
Experimental Neurobiology, ISSN: 2093-8144, Vol: 28, Issue: 1, Page: 17-29
2019
- 6Citations
- 19Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
5-HT receptor (5-HTR) is implicated in cognitive dysfunction, mood disorder, psychosis, and eating disorders. However, despite its significant role in regulating the brain functions, regulation of 5-HTR at the molecular level is poorly understood. Here, using yeast two-hybrid assay, we found that human 5-HTR directly binds to neuro-oncological ventral antigen 1 (Nova-1), a brain-enriched splicing regulator. The interaction between 5-HTR and Nova-1 was confirmed using GST pull-down and co-immunoprecipitation assays in cell lines and rat brain. The splicing activity of Nova-1 was decreased upon overexpression of 5-HTR, which was examined by detecting the spliced intermediates of gonadotropin-releasing hormone (GnRH), a known pre-mRNA target of Nova-1, using RT-PCR. In addition, overexpression of 5-HTR induced the translocation of Nova-1 from the nucleus to cytoplasm, resulting in the reduced splicing activity of Nova-1. In contrast, overexpression of Nova-1 reduced the activity and the total protein levels of 5-HTR. Taken together, these results indicate that when the expression levels of 5-HTR or Nova-1 protein are not properly regulated, it may also deteriorate the function of the other.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85067888899&origin=inward; http://dx.doi.org/10.5607/en.2019.28.1.17; http://www.ncbi.nlm.nih.gov/pubmed/30853821; http://www.en-journal.org/journal/view.html?doi=10.5607/en.2019.28.1.17; https://dx.doi.org/10.5607/en.2019.28.1.17; https://www.en-journal.org/journal/view.html?doi=10.5607/en.2019.28.1.17
The Korean Society for Brain and Neural Science
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