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Parallel evolution of influenza across multiple spatiotemporal scales

eLife, ISSN: 2050-084X, Vol: 6
2017
  • 101
    Citations
  • 0
    Usage
  • 180
    Captures
  • 45
    Mentions
  • 89
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    101
  • Captures
    180
  • Mentions
    45
    • News Mentions
      35
      • News
        35
    • Blog Mentions
      10
      • Blog
        10
  • Social Media
    89
    • Shares, Likes & Comments
      89
      • Facebook
        89

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Article Description

Viral variants that arise in the global influenza population begin as de novo mutations in single infected hosts, but the evolutionary dynamics that transform within-host variation to global genetic diversity are poorly understood. Here, we demonstrate that influenza evolution within infected humans recapitulates many evolutionary dynamics observed at the global scale. We deep-sequence longitudinal samples from four immunocompromised patients with long-term H3N2 influenza infections. We find parallel evolution across three scales: within individual patients, in different patients in our study, and in the global influenza population. In hemagglutinin, a small set of mutations arises independently in multiple patients. These same mutations emerge repeatedly within single patients and compete with one another, providing a vivid clinical example of clonal interference. Many of these recurrent within-host mutations also reach a high global frequency in the decade following the patient infections. Our results demonstrate surprising concordance in evolutionary dynamics across multiple spatiotemporal scales.

Bibliographic Details

Xue, Katherine S; Stevens-Ayers, Terry; Campbell, Angela P; Englund, Janet A; Pergam, Steven A; Boeckh, Michael; Bloom, Jesse D

eLife Sciences Publications, Ltd

Neuroscience; Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology

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