A double-sided microscope to realize whole-ganglion imaging of membrane potential in the medicinal leech
eLife, ISSN: 2050-084X, Vol: 6
2017
- 14Citations
- 31Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations14
- Citation Indexes14
- CrossRef14
- 12
- Captures31
- Readers31
- 31
Article Description
Studies of neuronal network emergence during sensory processing and motor control are greatly facilitated by technologies that allow us to simultaneously record the membrane potential dynamics of a large population of neurons in single cell resolution. To achieve whole-brain recording with the ability to detect both small synaptic potentials and action potentials, we developed a voltage-sensitive dye (VSD) imaging technique based on a double-sided microscope that can image two sides of a nervous system simultaneously. We applied this system to the segmental ganglia of the medicinal leech. Double-sided VSD imaging enabled simultaneous recording of membrane potential events from almost all of the identifiable neurons. Using data obtained from double-sided VSD imaging, we analyzed neuronal dynamics in both sensory processing and generation of behavior and constructed functional maps for identification of neurons contributing to these processes.
Bibliographic Details
10.7554/elife.29839; 10.7554/elife.29839.013; 10.7554/elife.29839.007; 10.7554/elife.29839.021; 10.7554/elife.29839.011; 10.7554/elife.29839.009; 10.7554/elife.29839.015; 10.7554/elife.29839.020; 10.7554/elife.29839.002; 10.7554/elife.29839.001; 10.7554/elife.29839.016; 10.7554/elife.29839.003; 10.7554/elife.29839.012; 10.7554/elife.29839.014
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