Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury
eLife, ISSN: 2050-084X, Vol: 7
2018
- 103Citations
- 240Captures
- 2Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations103
- Citation Indexes103
- 103
- CrossRef70
- Captures240
- Readers240
- 239
- Mentions2
- News Mentions2
- News2
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Mechanisms of Vagus Nerve Stimulation in Improving Motor Dysfunction After Stroke
Introduction Stroke is the leading cause of long-term disability worldwide, with 80% of patients suffering from motor dysfunction on one side of the body, which
Article Description
Recovery from serious neurological injury requires substantial rewiring of neural circuits. Precisely-timed electrical stimulation could be used to restore corrective feedback mechanisms and promote adaptive plasticity after neurological insult, such as spinal cord injury (SCI) or stroke. This study provides the first evidence that closed-loop vagus nerve stimulation (CLV) based on the synaptic eligibility trace leads to dramatic recovery from the most common forms of SCI. The addition of CLV to rehabilitation promoted substantially more recovery of forelimb function compared to rehabilitation alone following chronic unilateral or bilateral cervical SCI in a rat model. Triggering stimulation on the most successful movements is critical to maximize recovery. CLV enhances recovery by strengthening synaptic connectivity from remaining motor networks to the grasping muscles in the forelimb. The benefits of CLV persist long after the end of stimulation because connectivity in critical neural circuits has been restored.
Bibliographic Details
10.7554/elife.32058; 10.7554/elife.32058.007; 10.7554/elife.32058.017; 10.7554/elife.32058.003; 10.7554/elife.32058.008; 10.7554/elife.32058.009; 10.7554/elife.32058.011; 10.7554/elife.32058.018; 10.7554/elife.32058.002; 10.7554/elife.32058.010; 10.7554/elife.32058.006; 10.7554/elife.32058.001
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85045613456&origin=inward; http://dx.doi.org/10.7554/elife.32058; http://www.ncbi.nlm.nih.gov/pubmed/29533186; https://elifesciences.org/articles/32058#video2; http://dx.doi.org/10.7554/elife.32058.007; https://elifesciences.org/articles/32058#fig3; http://dx.doi.org/10.7554/elife.32058.017; https://elifesciences.org/articles/32058#fig1; http://dx.doi.org/10.7554/elife.32058.003; https://elifesciences.org/articles/32058#video3; http://dx.doi.org/10.7554/elife.32058.008; https://elifesciences.org/articles/32058#video4; http://dx.doi.org/10.7554/elife.32058.009; https://elifesciences.org/articles/32058#fig2; http://dx.doi.org/10.7554/elife.32058.011; https://elifesciences.org/articles/32058; https://elifesciences.org/articles/32058#fig4; http://dx.doi.org/10.7554/elife.32058.018; https://elifesciences.org/articles/32058#digest; http://dx.doi.org/10.7554/elife.32058.002; https://elifesciences.org/articles/32058#video5; http://dx.doi.org/10.7554/elife.32058.010; https://elifesciences.org/articles/32058#video1; http://dx.doi.org/10.7554/elife.32058.006; https://elifesciences.org/articles/32058#abstract; http://dx.doi.org/10.7554/elife.32058.001; https://dx.doi.org/10.7554/elife.32058
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