The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice
eLife, ISSN: 2050-084X, Vol: 7
2018
- 20Citations
- 57Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations20
- Citation Indexes20
- 20
- CrossRef18
- Captures57
- Readers57
- 57
Article Description
Brain computations rely on a proper balance between excitation and inhibition which progressively emerges during postnatal development in rodent. g-Aminobutyric acid (GABA) neurotransmission supports inhibition in the adult brain but excites immature rodent neurons. Alterations in the timing of the GABA switch contribute to neurological disorders, so unveiling the involved regulators may be a promising strategy for treatment. Here we show that the adipocyte hormone leptin sets the tempo for the emergence of GABAergic inhibition in the newborn rodent hippocampus. In the absence of leptin signaling, hippocampal neurons show an advanced emergence of GABAergic inhibition. Conversely, maternal obesity associated with hyperleptinemia delays the excitatory to inhibitory switch of GABA action in offspring. This study uncovers a developmental function of leptin that may be linked to the pathogenesis of neurological disorders and helps understanding how maternal environment can adversely impact offspring brain development.
Bibliographic Details
10.7554/elife.36726; 10.7554/elife.36726.012; 10.7554/elife.36726.001; 10.7554/elife.36726.010; 10.7554/elife.36726.008; 10.7554/elife.36726.002
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85053898903&origin=inward; http://dx.doi.org/10.7554/elife.36726; http://www.ncbi.nlm.nih.gov/pubmed/30106375; https://elifesciences.org/articles/36726#fig4; http://dx.doi.org/10.7554/elife.36726.012; https://elifesciences.org/articles/36726#abstract; http://dx.doi.org/10.7554/elife.36726.001; https://elifesciences.org/articles/36726#fig3; http://dx.doi.org/10.7554/elife.36726.010; https://elifesciences.org/articles/36726#fig2; http://dx.doi.org/10.7554/elife.36726.008; https://elifesciences.org/articles/36726#fig1; http://dx.doi.org/10.7554/elife.36726.002; https://elifesciences.org/articles/36726; https://dx.doi.org/10.7554/elife.36726
eLife Sciences Publications, Ltd
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