Panton-valentine leucocidin is the key determinant of staphylococcus aureus pyomyositis in a bacterial GWAS
eLife, ISSN: 2050-084X, Vol: 8
2019
- 52Citations
- 24Usage
- 89Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations52
- Citation Indexes52
- CrossRef52
- 47
- Usage24
- Downloads20
- Abstract Views4
- Captures89
- Readers89
- 89
Article Description
Pyomyositis is a severe bacterial infection of skeletal muscle, commonly affecting children in tropical regions, predominantly caused by Staphylococcus aureus. To understand the contribution of bacterial genomic factors to pyomyositis, we conducted a genome-wide association study of S. aureus cultured from 101 children with pyomyositis and 417 children with asymptomatic nasal carriage attending the Angkor Hospital for Children, Cambodia. We found a strong relationship between bacterial genetic variation and pyomyositis, with estimated heritability 63.8% (95% CI 49.2-78.4%). The presence of the Panton-Valentine leucocidin (PVL) locus increased the odds of pyomyositis 130-fold (p=10- ). The signal of association mapped both to the PVL-coding sequence and the sequence immediately upstream. Together these regions explained over 99.9% of heritability (95% CI 93.5-100%). Our results establish staphylococcal pyomyositis, like tetanus and diphtheria, as critically dependent on a single toxin and demonstrate the potential for association studies to identify specific bacterial genes promoting severe human disease.
Bibliographic Details
10.7554/elife.42486; 10.7554/elife.42486.001; 10.7554/elife.42486.005; 10.7554/elife.42486.002; 10.7554/elife.42486.003
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85064197618&origin=inward; http://dx.doi.org/10.7554/elife.42486; http://www.ncbi.nlm.nih.gov/pubmed/30794157; https://elifesciences.org/articles/42486#abstract; http://dx.doi.org/10.7554/elife.42486.001; https://elifesciences.org/articles/42486#fig2; http://dx.doi.org/10.7554/elife.42486.005; https://elifesciences.org/articles/42486#digest; http://dx.doi.org/10.7554/elife.42486.002; https://elifesciences.org/articles/42486; https://elifesciences.org/articles/42486#fig1; http://dx.doi.org/10.7554/elife.42486.003; https://dc.etsu.edu/etsu-works/10029; https://dc.etsu.edu/cgi/viewcontent.cgi?article=11295&context=etsu-works; https://dx.doi.org/10.7554/elife.42486
eLife Sciences Publications, Ltd
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