A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease
eLife, ISSN: 2050-084X, Vol: 10, Page: 0
2021
- 26Citations
- 33Usage
- 47Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations26
- Citation Indexes26
- 26
- CrossRef22
- Usage33
- Downloads27
- Abstract Views6
- Captures47
- Readers47
- 47
Article Description
Bone marrow adipocytes accumulate with age and in diverse disease states. However, their origins and adaptations in these conditions remain unclear, impairing our understanding of their context-specific endocrine functions and relationship with surrounding tissues. In this study, by analyzing bone and adipose tissues in the lipodystrophic ‘fat-free’ mouse, we define a novel, secondary adipogenesis pathway that relies on the recruitment of adiponectin-negative stromal progenitors. This pathway is unique to the bone marrow and is activated with age and in states of metabolic stress in the fat-free mouse model, resulting in the expansion of bone marrow adipocytes specialized for lipid storage with compromised lipid mobilization and cytokine expression within regions traditionally devoted to hematopoiesis. This finding further distinguishes bone marrow from peripheral adipocytes and contributes to our understanding of bone marrow adipocyte origins, adaptation, and relationships with surrounding tissues with age and disease.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85114086648&origin=inward; http://dx.doi.org/10.7554/elife.66275; http://www.ncbi.nlm.nih.gov/pubmed/34378533; https://elifesciences.org/articles/66275; https://digitalcommons.wustl.edu/open_access_pubs/10862; https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=11859&context=open_access_pubs; https://dx.doi.org/10.7554/elife.66275
eLife Sciences Publications, Ltd
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