Mutations in the BRCA1 gene (185delAG and 5382insC) are not present in any of the 30 breast cancer patients analyzed from eastern Colombia
Biomedica, ISSN: 0120-4157, Vol: 29, Issue: 1, Page: 61-72
2009
- 6Citations
- 89Captures
- 1Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Most Recent News
BRCA1 and BRCA2 mutations in a sample of breast and ovarian cancer families from the Colombian pacific/Mutaciones en los genes BRCA1 y BRCA2 en una muestra de familias con cancer de mama y/u ovario del pacifico colombiano.(ORIGINAL ARTICLE texto en ingles
Introduction Breast Cancer (BC) is the most common type of cancer among women, with an estimated value of 1.67 million new cancer cases diagnosed in
Article Description
Introduction: Breast cancer is considered a worldwide public health problem, and, in Santander Province, Colombia, it is the first leading cause of morbidity and mortality by cancer in women. All cancers are considered genetic diseases, and mutations in BRCA (BReast CAncer) genes raises the risk for breast cancer by 60%-80%. The current study searched for the two most frequent BRCA1 mutations reported in the Breast Cancer Core Information database. Objective: The presence of specific mutations (185delAG, exon 2 and 5382insC, exon 20) was determined for the BRCA1 gene in women with familial/hereditary breast cancer. Materials and methods: The sample included 30 female patients using the oncology services in Bucaramanga, eastern Colombia; an informed consent, a questionnaire and a blood sample were obtained from each. The molecular analysis was done with PCR-Mismatch, to detect the insertion or eliminatation of a restriction site, and enzymatic digestion methods (HinfI or DdeI). Results: Two of the most frequent BRCA1 mutations in the international database were not found in the 30 patients studied. Conclusion: Additional mutation screening techniques are necessary involving the entire BRCA1 gene, are necessary in order to better characterize the molecular epidemiology of breast cancer in Bucaramanga, Santander, Colombia.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70350457820&origin=inward; http://dx.doi.org/10.7705/biomedica.v29i1.42; http://www.revistabiomedica.org/index.php/biomedica/article/view/42; http://www.revistabiomedica.org/index.php/biomedica/article/download/42/43; https://dx.doi.org/10.7705/biomedica.v29i1.42; https://revistabiomedica.org/index.php/biomedica/article/view/42
Instituto Nacional de Salud (Colombia)
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know