Impacts of ozone treatment and its relationship with IGF-1 levels after injury of soft tissue: An experimental study in rats model
Kafkas Universitesi Veteriner Fakultesi Dergisi, ISSN: 1309-2251, Vol: 23, Issue: 6, Page: 967-991
2017
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Article Description
To investigate the effects of ozone treatment on soft tissue injury and to observe whether there is an alteration in serum IGF-1 levels after ozone treatment in an experimental rat model. Twenty-four adult Wistar albino 240-350 g male rats were randomly allocated into two groups. A standardized, experimental soft tissue injury was created on left hind limbs of animals. Group 1 underwent daily ozone treatment intraperitoneally (20 µg/mL), while Group 2 received only nutrition and routine care. All rats were evaluated regarding body weight and sensory and motor function on 5 and 15 days after experimental trauma. Blood samples were drawn from intracardiac in group 1 and group 2 serum levels of IGF-1 level were measured at the day of 15. During follow-up period after formation of soft tissue injury, three rats in Group 2 had cutaneous infection that responded well to topical tetracycline treatment. Two groups displayed similar results regarding sensory and motor functions on 5 and 15 days. Serum IGF-1 level in Group 1 was significantly higher than that of Group 1 (P=0.03). Serum IGF-1 level was correlated with motor function on day 15 in Group 1 (P=0.04) and with motor function on day 5 in Group 2 (P=0.011). Ozone treatment may have favorable impacts on healing and regeneration process in connective and muscle tissues and these beneficial effects may be mediated by IGF-1. Further research is warranted to elucidate the role of IGF-1 in repair process and to provide additional new insights to the treatment strategies.
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