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Fragile histidine triad expression delays tumor development and induces apoptosis in human pancreatic cancer

Cancer Research, ISSN: 0008-5472, Vol: 61, Issue: 12, Page: 4827-4836
2001
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Article Description

The fragile histidine triad (FHIT) gene is a tumor suppressor gene that is altered by deletion in a large fraction of human tumors, including pancreatic cancer. To evaluate the potential of FHIT gene therapy, we developed recombinant adenoviral and adenoassociated viral (AAV) FHIT vectors and tested these vectors in vitro and in viva for activity against human pancreatic cancer cells. Our data show that viral FHIT gene delivery results in apoptosis by activation of the caspase pathway. Furthermore, Fhit overexpression enhances the susceptibility of pancreatic cancer cells to exogenous inducers of apoptosis. In viva results show that FHIT gene transfer delays tumor growth and prolongs survival in a murine model mimicking human disease.

Bibliographic Details

Kristoffel R. Dumon; Hideshi Ishii; Andrea Vecchione; Francesco Trapasso; Gustavo Baldassarre; Fatima Chakrani; Teresa Druck; Raffaele Baffa; Matthew J. During; Kay Huebner; Carlo M. Croce; Ernest F. Rosato; Noel N. Williams

Medicine; Biochemistry, Genetics and Molecular Biology

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