Role of PKC-δ activity in glutathione-depleted neuroblastoma cells
Free Radical Biology and Medicine, ISSN: 0891-5849, Vol: 35, Issue: 5, Page: 504-516
2003
- 49Citations
- 18Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations49
- Citation Indexes49
- 49
- CrossRef39
- Captures18
- Readers18
- 18
Article Description
Protein kinases C (PKCs) are a family of isoenzymes sensitive to oxidative modifications and involved in the transduction signal pathways that regulate cell growth. As such, they can act as cellular sensors able to intercept intracellular redox changes and promote the primary adaptive cell response. In this study, we have demonstrated that PKC isoforms are specifically influenced by the amount of intracellular glutathione (GSH). The greatest GSH depletion is associated with a maximal reactive oxygen species (ROS) production and accompanied by an increase in the activity of the δ isoform and a concomitant inactivation of α. ROS generation induced early morphological changes in GSH-depleted neuroblastoma cells characterized, at the intracellular level, by the modulation of PKC-δ activity that was involved in the pathway leading to apoptosis. When cells were pretreated with rottlerin, their survival was improved by the ability of this compound to inhibit the activity of PKC-δ and to counteract ROS production. These results define a novel role of PKC-δ in the cell signaling pathway triggered by GSH loss normally associated with many neurodegenerative diseases and clinically employed in the treatment of neuroblastoma.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0891584903003320; http://dx.doi.org/10.1016/s0891-5849(03)00332-0; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=10744226728&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/12927600; http://linkinghub.elsevier.com/retrieve/pii/S0891584903003320; http://api.elsevier.com/content/article/PII:S0891584903003320?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0891584903003320?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0891584903003320; http://dx.doi.org/10.1016/s0891-5849%2803%2900332-0; https://dx.doi.org/10.1016/s0891-5849%2803%2900332-0
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know