Axial diffusivity is the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord: A quantitative pixelwise analysis
Journal of Neuroscience, ISSN: 0270-6474, Vol: 29, Issue: 9, Page: 2805-2813
2009
- 420Citations
- 276Captures
- 8Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations420
- Citation Indexes420
- 420
- CrossRef366
- Captures276
- Readers276
- 276
- Mentions8
- News Mentions5
- 5
- Blog Mentions3
- 3
Most Recent Blog
Here's What That All-Nighter is Doing to Your Brain
Skipping a night of sleep to work on a project or study for an exam is something many of us have done at one time
Most Recent News
Those All-Nighters You Pull May Not Be As Harmless As You Think
As you put the finishing touches on your paper, you notice the sun rising and fantasize about crawling in bed. Your vision and hearing are
Article Description
The dissociation between magnetic resonance imaging (MRI) and permanent disability in multiple sclerosis (MS), termed the clinicoradiological paradox, can primarily be attributed to the lack of specificity of conventional, relaxivity-based MRI measurements in detecting axonal damage, the primary pathological correlate of long-term impairment in MS. Diffusion tensor imaging (DTI) has shown promise in specifically detecting axonal damage and demyelination in MS and its animal model, experimental autoimmune encephalomyelitis (EAE). To quantify the specificity of DTI in detecting axonal injury, in vivo DTI maps from the spinal cords of mice with EAE and quantitative histological maps were both registered to a common space. A pixelwise correlation analysis between DTI parameters, histological metrics, and EAE scores revealed a significant correlation between the water diffusion parallel to the white matter fibers, or axial diffusivity, and EAE score. Furthermore, axial diffusivity was the primary correlate of quantitative staining for neurofilaments (SMI31), markers of axonal integrity. Both axial diffusivity and neurofilament staining were decreased throughout the entire white matter, not solely within the demyelinated lesions seen in EAE. In contrast, although anisotropy was significantly correlated with EAE score, it was not correlated with axonal damage. The results demonstrate a strong, quantitative relationship between axial diffusivity and axonal damage and show that anisotropy is not specific for axonal damage after inflammatory demyelination. Copyright © 2009 Society for Neuroscience.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=63849246613&origin=inward; http://dx.doi.org/10.1523/jneurosci.4605-08.2009; http://www.ncbi.nlm.nih.gov/pubmed/19261876; https://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.4605-08.2009; https://dx.doi.org/10.1523/jneurosci.4605-08.2009; https://www.jneurosci.org/content/29/9/2805
Society for Neuroscience
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know