Chapter 20 Regulated Exocytosis from Astrocytes
International Review of Neurobiology, ISSN: 0074-7742, Vol: 85, Page: 261-293
2009
- 19Citations
- 36Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations19
- Citation Indexes19
- 19
- CrossRef13
- Captures36
- Readers36
- 29
Review Description
Astrocytes have traditionally been considered ancillary, satellite cells of the nervous system. However, it is a very recent acquisition that glial cells generate signaling loops which are integral to the brain circuitry and participate, interactively with neuronal networks, in the processing of information. Such a conceptual breakthrough makes this field of investigation one of the hottest in neuroscience, as it calls for a revision of past theories of brain function as well as for new strategies of experimental exploration of brain function. Glial cells are electrically not excitable, and it was only the use of optical recording techniques together with calcium sensitive dyes, that allowed the chemical excitability of glial cells to become apparent. Studies using these new techniques have shown for the first time that glial cells are activated by surrounding synaptic activity and translate neuronal signals into their own calcium code. Intracellular calcium concentration([Ca 2+ ] i ) elevations in glial cells have then shown to underlie spatial transfer of information in the glial network, accompanied by release of chemical transmitters (gliotransmitters) such as glutamate and back‐signaling to neurons. As a consequence, optical imaging techniques applied to cell cultures or intact tissue have become a state‐of‐the‐art technology for studying glial cell signaling. The molecular mechanisms leading to release of “gliotransmitters,” especially glutamate, from glia are under debate. Accumulating evidence clearly indicates that astrocytes secrete numerous transmitters by Ca 2+ ‐dependent exocytosis. This review will discuss the mechanisms underlying the release of chemical transmitters from astrocytes with a particular emphasis to the regulated exocytosis processes.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0074774209850204; http://dx.doi.org/10.1016/s0074-7742(09)85020-4; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=67650093340&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/19607976; https://linkinghub.elsevier.com/retrieve/pii/S0074774209850204; http://linkinghub.elsevier.com/retrieve/pii/S0074774209850204; http://dx.doi.org/10.1016/s0074-7742%2809%2985020-4; https://dx.doi.org/10.1016/s0074-7742%2809%2985020-4
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know