The in utero initiation with DMN alters the complement of cytosolic glutathione S-transferases and the phenobarbital-induced expression of c-jun and c-myc oncogenes in primary neonatal rat hepatocytes
Cytotechnology, ISSN: 0920-9069, Vol: 11, Issue: 1 Supplement, Page: S18-20
1993
- 3Citations
- 10Captures
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Article Description
As revealed by a novel in utero-in vitro hepatocarcinogenesis model, a single exposure to dimethylnitrosamine (DMN) elicited in postnatal (and fetal) primary rat hepatocytes (i) immunocytochemically detectable, widespread increases in their complement of the alpha, mu and especially pi classes of cytosolic glutathione S-transferases (GST's); and (ii) changed patterns (with respect to controls) of the phenobarbital (PB)-evoked increases in steady state levels of c-jun and c-myc mRNA's. These results indicate that DMN causes both transient cytotoxic effects and a broad, permanent initiation in fetal proliferating hepatocytes. © 1993 Kluwer Academic Publishers.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0027351051&origin=inward; http://dx.doi.org/10.1007/bf00746044; http://www.ncbi.nlm.nih.gov/pubmed/22358698; http://link.springer.com/10.1007/BF00746044; https://dx.doi.org/10.1007/bf00746044; https://link.springer.com/article/10.1007/BF00746044; http://www.springerlink.com/index/10.1007/BF00746044; http://www.springerlink.com/index/pdf/10.1007/BF00746044
Springer Nature
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