Changes in glutamate receptor subunits within the medulla in goats after section of the carotid sinus nerves
Journal of Applied Physiology, ISSN: 1522-1601, Vol: 116, Issue: 12, Page: 1531-1542
2014
- 8Citations
- 3Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations8
- Citation Indexes8
- CrossRef4
- Captures3
- Readers3
Article Description
The mechanisms which contribute to the time-dependent recovery of resting ventilation and the ventilatory CO chemoreflex after carotid body denervation (CBD) are poorly understood. Herein we tested the hypothesis that there are time-dependent changes in the expression of specific AMPA, NMDA, and/or neurokinin-1 (NK1R) receptors within respiratory-related brain stem nuclei acutely or chronically after CBD in adult goats. Brain stem tissues were collected acutely (5 days) or chronically (30 days) after sham or bilateral CBD, immunostained with antibodies targeting AMPA (GluA1 or GluA2), NMDA (GluN1), or NK-1 receptors, and optical density (OD) compared. Physiological measurement confirmed categorization of each group and showed ventilatory effects consistent with bilateral CBD (Miller et al. J Appl Physiol 115: 1088-1098, 2013). Acutely after CBD, GluA1 OD was unchanged or slightly increased, but GluA2 and GluN1 OD were reduced 15-30% within the nucleus tractus solitarius (NTS) and in other medullary respiratory nuclei. Chronically after CBD, GluA1 was reduced (P < 0.05) within the caudal NTS and in other nuclei, but there was significant recovery of GluA2 and GluN1 OD. NK1 OD was not significantly different from control after CBD. We conclude that the initial decrease in GluA2 and GluN1 after CBD likely contributes to hypoventilation and the reduced CO chemoreflex. The partial recovery of ventilation and the CO chemoreflex after CBD parallel a time-dependent return of these receptors to near control levels but likely depend upon additional initiating and maintenance factors for neuroplasticity. Copyright © 2014 the American Physiological Society.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84902472363&origin=inward; http://dx.doi.org/10.1152/japplphysiol.00216.2014; http://www.ncbi.nlm.nih.gov/pubmed/24790015; https://www.physiology.org/doi/10.1152/japplphysiol.00216.2014; http://jap.physiology.org/cgi/doi/10.1152/japplphysiol.00216.2014; http://jap.physiology.org/content/116/12/1531; http://jap.physiology.org/lookup/doi/10.1152/japplphysiol.00216.2014; http://jap.physiology.org/content/116/12/1531.abstract; http://jap.physiology.org/content/jap/116/12/1531.full.pdf
American Physiological Society
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