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Two cytochromes P450 catalyze S-heterocyclizations in cabbage phytoalexin biosynthesis

Nature Chemical Biology, ISSN: 1552-4469, Vol: 11, Issue: 11, Page: 837-839
2015
  • 39
    Citations
  • 0
    Usage
  • 101
    Captures
  • 2
    Mentions
  • 42
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    39
  • Captures
    101
  • Mentions
    2
    • References
      2
      • Wikipedia
        2
  • Social Media
    42
    • Shares, Likes & Comments
      42
      • Facebook
        42

Article Description

Phytoalexins are abundant in edible crucifers and have important biological activities, yet no dedicated gene for their biosynthesis is known. Here, we report two new cytochromes P450 from Brassica rapa (Chinese cabbage) that catalyze unprecedented S-heterocyclizations in cyclobrassinin and spirobrassinin biosynthesis. Our results provide genetic and biochemical insights into the biosynthesis of a prominent pair of dietary metabolites and have implications for pathway discovery across >20 recently sequenced crucifers.

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