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Different omega-3 formulations yield to diverse clinical response: A case-report

Current Drug Safety, ISSN: 1574-8863, Vol: 11, Issue: 2, Page: 177-180
2016
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Article Description

Treatment guidelines recommend omega-3 with Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA) content not above 85% in patients with high plasma levels of triglycerides. Since the different up to date formulation of omega-3 available in commerce must be similar to clinical efficacy and safety, herein, we report the case a 52-year-old woman who presented clinical inefficacy using Olevia® omega-3 treatment. Clinical evaluation excluded the presence of intestinal or systemic diseases able to reduce the drug absorption. Switching the therapy from (Olevia®) to an equivalent omega-3 formulation (Esapent®), we documented a decrease in her plasma triglycerides levels. In order to evaluate a possible difference between these formulations we performed a single blind in vitro dissolution test using three pills for each formulation of omega-3 (Olevia®, Esapent® and another one chosen between the several formulations available in commerce: DOC Generic®) that revealed a significant difference (> 20%) in the dissolution time of three different omega- 3 commercially available drug formulation.

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