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Target volume delineation based on diffusion-weighted magnetic resonance imaging for locally advanced head and neck cancer

Anticancer Research, ISSN: 1791-7530, Vol: 36, Issue: 8, Page: 4181-4185
2016
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Article Description

Aim: To compare gross tumor volume (GTV) definition in locally advanced head and neck squamous cell carcinoma (LAHNSCC) using diffusion-weighted magnetic resonance imaging (DW-MRI) and computed tomography (CT) with intravenous contrast. Patients and Methods: Patients with LAHNSCC were imaged with CT and DW-MRI before treatment. GTV was delineated in both CT and DWMRI images by two investigators. CT and MRI images were co-registered and volume data were extracted for statistical analysis. Results: In general, DW-MRI volumes [based on the apparent diffusion coefficient (ADC)] were smaller than CT-based volumes. For all patients, GTV delineation based on pre-treatment DW-MRI was significantly smaller than that based on CT scan (CT-GTV) (p=0.0078). The mean difference (95% limits of agreement) between the two investigators was-0.37 cm3 for CT-GTV and 0.17 cm3 for ADC-GTV measurements, respectively. Conclusion: DWMRI radiotherapy GTVs are smaller than CT-based targets with less interobserver variability. Further validation of these preliminary results is necessary in a much larger patient group.

Bibliographic Details

DE Felice, Francesca; Musio, Daniela; Bulzonetti, Nadia; Maghella, Fabrizio; Tombolini, Vincenzo

Medicine; Biochemistry, Genetics and Molecular Biology

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