Modifications of plasma lipoproteins after lipase activation in patients with chylomicronemia
Journal of Lipid Research, ISSN: 0022-2275, Vol: 27, Issue: 12, Page: 1248-1258
1986
- 16Citations
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations16
- Citation Indexes16
- 16
Article Description
Lipoprotein lipase (LPL) and hepatic lipase (HL) are enzymatic activities involved in lipoprotein metabolism. The purpose of this study was to analyze the physicochemical modifications of plasma lipoproteins produced by LPL activation in two patients with apoC-II deficiency syndrome and by HL activation in two patients with LPL deficiency. LPL activation was achieved by the infusion of normal plasma containing apoC-II and HL was released by the injection of heparin. Lipoproteins were analyzed by ultracentrifugation in a zonal rotor under rate flotation conditions before and after lipase activation. The LPL activation resulted in: 1) a reduction of plasma triglycerides; 2) a reduction of fast-floating very low density lipoprotein (VLDL) concentration; 3) an increase of intermediate density lipoprotein (IDL), which maintained unaltered flotation properties; 4) an increase of low density lipoproteins (LDL) accompanied by modifications of their flotation rates and composition; 5) no significant variations of high density lipoprotein (HDL) levels; and 6) an increase of the HDL flotation rate. The HL activation resulted in: 1) a slight reduction of plasma triglycerides; 2) a reduction of the relative triglyceride content of slow-floating VLDL, IDL, LDL, and HDL accompanied by an increase of phospholipid in VLDL and by an increase of cholesteryl ester in IDL; and 3) a reduction of the HDL flotation rate. These experiments in chylomicronemic patients provide in vivo evidence that LPL and HL are responsible for plasma triglyceride hydrolysis of different lipoproteins, and that LPL is particularly involved in determining the levels and physicochemical properties of LDL. Moreover, in these patients, the LPL activation does not directly change the HDL levels, and LPL or HL does not produce a step-wise conversion of HDL to HDL (or vice versa) but rather modifies the flotation rates of all the HDL molecules present in plasma.
Bibliographic Details
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know