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Plasma and cerebrospinal fluid tryptophan in multiple sclerosis and degenerative diseases

Journal of Neurology, Neurosurgery and Psychiatry, ISSN: 0022-3050, Vol: 42, Issue: 7, Page: 640-641
1979
  • 105
    Citations
  • 0
    Usage
  • 41
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    105
  • Captures
    41
  • Mentions
    1
    • News Mentions
      1
      • News
        1

Most Recent News

Are 5HT7 Receptors Possible Target for Multiple Sclerosis?

Antony Justin*, Deepthi Murugan, Meghana Basavaraj, Ashwini Prem Kumar Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty 643

Article Description

Tryptophan and competing neutral amino acid levels were found to be diminished in the plasma of patients with multiple sclerosis and degenerative diseases, the greatest decrease being of tryptophan. Cerebrospinal fluid tryptophan was decreased in multiple sclerosis and motor neurone disease, while leucine and valine were increased. These changes might lead to decreased synthesis of brain serotonin and brain proteins. The ratio between neutral amino acids and tryptophan might be used as an ancillary test in the screening of degenerative diseases.

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