The primary tissue culture of human adrenocortical Conn's adenomata
Pathology - Research and Practice, ISSN: 0344-0338, Vol: 173, Issue: 1, Page: 66-81
1981
- 6Citations
- 2Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations6
- Citation Indexes6
- CrossRef6
- Captures2
- Readers2
Article Description
Primary cultures of dissociated parenchymal cells from Conn's adenomata causing primary hyperaldosteronism were successfully set up by a method previously used with normal adult human and rat adrenocortical tissue. In such cultures the adenomatous cells largely prevailed (making up 87% of the whole cell population), could survive for lengthy terms (at least up to 30 days), and were endowed with a spontaneous, discrete capability to proliferate. The de novo RNA- and DNA-synthetic and mitotic activities of Conn's cells were markedly stimulated in cultures exposed between day 16 and 21 to daily doses of exogenous cyclic AMP, either alone or in equimolar association with cyclic GMP. A significantly weaker, though still prominent enhancement of adenomatous cell growth was elicited also by daily administrations of an equimolar mixture of ACTH 1-24 and angiotensin II. In contrast, little stimulation or inhibition of growth or no effect at all could be observed when cyclic GMP, ACTH 1-24, and angiotensin II were respectively administered, each by itself.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0344033881800088; http://dx.doi.org/10.1016/s0344-0338(81)80008-8; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0019776850&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/6278459; https://linkinghub.elsevier.com/retrieve/pii/S0344033881800088; http://linkinghub.elsevier.com/retrieve/pii/S0344033881800088; http://api.elsevier.com/content/article/PII:S0344033881800088?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0344033881800088?httpAccept=text/plain; http://dx.doi.org/10.1016/s0344-0338%2881%2980008-8; https://dx.doi.org/10.1016/s0344-0338%2881%2980008-8
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