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The coeliac iceberg in Italy. A multicentre antigliadin antibodies screening for coeliac disease in school-age subjects

Acta Paediatrica, International Journal of Paediatrics, Supplement, ISSN: 0803-5326, Vol: 85, Issue: 412, Page: 29-35
1996
  • 408
    Citations
  • 0
    Usage
  • 107
    Captures
  • 3
    Mentions
  • 20
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    408
  • Captures
    107
  • Mentions
    3
    • Blog Mentions
      1
      • Blog
        1
    • News Mentions
      1
      • News
        1
    • References
      1
      • Wikipedia
        1
  • Social Media
    20
    • Shares, Likes & Comments
      20
      • Facebook
        20

Most Recent News

Should We All Copy Italy & Screen Kids for Celiac Disease?

Some are concerned that population screening could change symptomless people into patients, but a diagnosis could help prevent future complications. Medscape Medical News

Conference Paper Description

Background: Recent studies suggest that coeliac disease (CD) is one of the commonest, life-long disorders in Italy. The aims of this multicentre work were: (a) to establish the prevalence of CD on a nationwide basis; and (b) to characterize the CD clinical spectrum in Italy. Patients and methods: Fifteen centres screened 17201 students aged 6-15 years (68.6% of the eligible population) by the combined determination of serum IgG- and IgA-antigliadin antibody (AGA) test; 1289 (7.5%) were IgG and/or IgA-AGA positive and were recalled for the second-level investigation; 111 of them met the criteria for the intestinal biopsy: IgA-AGA positivity and/or AEA positivity or IgG-AGA positivity plus serum IgA deficiency. Results: Intestinal biopsy was performed on 98 of the 111 subjects. CD was diagnosed in 82 subjects (75 biopsy proven, 7 not biopsied but with associated AGA and AEA positivity). Most of the screening-detected coeliac patients showed low-grade intensity illness often associated with decreased psychophysical well-being. There were two AEA negative cases with associated CD and IgA deficiency. The prevalence of undiagnosed CD was 4.77 x 1000 (95% CI 3.79-5.91), 1 in 210 subjects. The overall prevalence of CD, including known CD cases, was 5.44 x 1000 (95% CI 4.57-6.44), 1 in 184 subjects. The ratio of known to undiagnosed CD cases was 1 in 7. Conclusions: These findings confirm that, in Italy, CD is one of the most common chronic disorders showing a wide and heterogeneous clinical spectrum. Most CD cases remain undiagnosed unless actively searched.

Bibliographic Details

C. Catassi; E. Fabiani; I. M. Rätsch; G. V. Coppa; P. L. Giorgi; R. Pierdomenico; S. Alessandrini; G. Iwanejko; R. Domenici; E. Mei; A. Miano; M. Marani; G. Bottaro; M. Spina; M. Dotti; A. Montanelli; M. Barbato; F. Viola; R. Lazzari; M. Vallini; G. Guariso; M. Plebani; F. Cataldo; G. Traverse; C. Ughi; G. Chiaravalloti; A. Ventura; M. Baldassarre; P. Scarcella; F. Bascietto; L. Ceglie; A. Valenti; P. Paolucci; M. Caradonna; E. Bravi

Wiley

Medicine

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