Building new drug delivery systems: In vitro and in vivo studies of drug-hydroxybutenyl cyclodextrin complexes
ACS Symposium Series, ISSN: 1947-5918, Vol: 1017, Page: 31-64
2009
- 2Citations
- 3Usage
- 12Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations2
- Citation Indexes2
- Usage3
- Abstract Views3
- Captures12
- Readers12
- 12
Conference Paper Description
In many respects, drug delivery is the perfect field for an organic chemist whose interest lies in structure-property relationships. Synthesis and characterization of a drug delivery system and subsequent introduction of a drug product incorporating this drug delivery technology into animals or humans is a complex and challenging structure-property problem. In this regard, we have developed hydroxybutenyl cyclodextrin (HBenCD) for oral and intravenous delivery of pharmaceutical actives having poor water solubility and low bioavailability. In this chapter, we summarize our recent research involving the synthesis and characterization of HBenCD, formation of drug-HBenCD complexes, in vitro solubility and dissolution studies of drug-HBenCD complexes, and pharmacokinetic studies in animals after oral and intravenous administration of drug-HBenCD complexes. © 2009 American Chemical Society.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84904817702&origin=inward; http://dx.doi.org/10.1021/bk-2009-1017.ch002; https://pubs.acs.org/doi/abs/10.1021/bk-2009-1017.ch002; https://dc.etsu.edu/etsu-works/17111; https://dc.etsu.edu/cgi/viewcontent.cgi?article=18377&context=etsu-works
American Chemical Society (ACS)
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