Modulation of PTEN by hexarelin attenuates coronary artery ligation-induced heart failure in rats
Turkish Journal of Medical Sciences, ISSN: 1303-6165, Vol: 49, Issue: 3, Page: 945-958
2019
- 7Citations
- 105Usage
- 3Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations7
- Citation Indexes7
- CrossRef3
- Usage105
- Downloads70
- Abstract Views35
- Captures3
- Readers3
Article Description
Background/aim: Hexarelin is a synthetic growth hormone-releasing peptide that exerts cardioprotective effects. However, itcardioprotective effect against heart failure (HF) is yet to be explained. This study investigated the therapeutic role of hexarelin and thmechanisms underlying its cardioprotective effects against coronary artery ligation (CAL)-induced HF in rats. Materials and methods: Rats with four weeks of permanent CAL, induced myocardial infarction, and HF were randomly separated into four groups: the control group (Ctrl), sham group (Sham), hexarelin treatment group (HF + Hx), and heart failure group (HF). The rats were treated with subcutaneous injection of hexarelin (100 µg/kg) in the treatment group or saline in the other groups twice a day for 30 days. Left ventricular (LV) function, oxidative stress, apoptosis, molecular analyses, and cardiac structural and pathological changes in rats were assessed. Results: The treatment of HF rats with hexarelin significantly induced the upregulation of phosphatase and tensin homologue (PTENexpression and inhibited the phosphorylation of protein kinase B (Akt) and mammalian target of rapamycin (mTOR) to significantlimprove LV function, ameliorate myocardial remodeling, and reduce oxidative stress. Conclusion: These findings indicate that hexarelin attenuates CAL-induced HF in rats by ameliorating myocardial remodeling, Ldysfunction, and oxidative stress via the upmodulation of PTEN signaling and downregulation of the Akt/mTOR signaling pathway.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85070256167&origin=inward; http://dx.doi.org/10.3906/sag-1812-49; http://www.ncbi.nlm.nih.gov/pubmed/31091855; https://journals.tubitak.gov.tr/medical/vol49/iss3/35; https://journals.tubitak.gov.tr/cgi/viewcontent.cgi?article=1835&context=medical; https://dx.doi.org/10.3906/sag-1812-49; https://journals.tubitak.gov.tr/medical/vol49/iss3/35/
The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS
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