Effects of captopril on melanin formation in B16 Cells
Journal of Food and Drug Analysis, ISSN: 1021-9498, Vol: 20, Issue: 3, Page: 668-673
2012
- 3Citations
- 1,131Usage
- 2Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations3
- Citation Indexes3
- Usage1,131
- Abstract Views1,020
- Downloads111
- Captures2
- Readers2
Article Description
The effect of captopril on melanin formation in B16 cells was investigated. In B16 intracellular model system, the effect of captopril on antityrosinase activity was found dose-dependent and correlated to its ability to suppress melanin formation. The copper chelation by captopril may in part be responsible for the inhibition of tyrosinase activity. Captopril also displayed a remarkable reducing ability and significantly inhibited ROS generation. Interestingly, captopril also significantly suppressed tyrosinase mRNA expression, as determined by reverse transcription-polymerase chain reaction (RT-PCR). Overall, the results showed that the protective effect of captopril makes it a potent inhibitor of melanin formation.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84870908772&origin=inward; http://dx.doi.org/10.6227/jfda.2012200314; https://www.jfda-online.com/journal/vol20/iss3/11; https://www.jfda-online.com/cgi/viewcontent.cgi?article=2158&context=journal; https://www.airitilibrary.com/Article/Detail/10219498-201209-201210150031-201210150031-668-673; https://dx.doi.org/10.6227/jfda.2012200314
衛生福利部食品藥物管理署
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