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Data for: Discovering Gene-Disease Associations with Biomedical Word Embeddings

2020
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    Citations
  • 188
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Dataset Description

This is the dataset supporting the publication Discovering Gene-Disease Associations with Biomedical Word Embeddings. Finding the right target for a disease is critical in the drug development process. This paper presents a machine learning approach for predicting gene-disease associations that (i) employs biomedical word embeddings as features for a classifier trained on Open Targets Platform (OTP) data that (ii) generalises beyond a specific disease or gene class. We train, evaluate and compare different word embedding models and classifiers for the task at hand. In addition, we validate the approach by training on a past OTP release and show that it can assist in identifying probable positive associations among current low evidence associations, confirmed by a recent OTP release. Furthermore, we train word embedding models on different time slices of biomedical articles from ScienceDirect and demonstrate that the trained classifier predicts associations that have not explicitly b...

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